Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor.

Aldinucci, Donatella; Poletto, Dalisa; Nanni, Paola; Degan, Massimo; Gloghini, Annunziata; Di Francia, Raffaele; Russo, Stefania; Carbone, Antonino; Pinto, Antonio; Gattei, Valter

Aldinucci, Donatella; Poletto, Dalisa; Nanni, Paola; Degan, Massimo; Gloghini, Annunziata; Di Francia, Raffaele; Russo, Stefania; Carbone, Antonino; Pinto, Antonio; Gattei, Valter.

Affiliation

Aldinucci D; Clinical and Experimental Haematology Research Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Istituto Nazionale Tumori, Aviano, Italy. daldinucci@cro.it

Br J Haematol ; 118(4): 1055-64, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12199785

Subject(s)

Fibroblasts/metabolism; Hodgkin Disease/metabolism; Proto-Oncogene Proteins c-kit/metabolism; Reed-Sternberg Cells/metabolism; Stem Cell Factor/metabolism; Apoptosis/drug effects; Cell Adhesion; Coculture Techniques; Hodgkin Disease/pathology; Humans; Interleukin-9/pharmacology; Lymph Nodes; Proto-Oncogene Proteins c-kit/analysis; Stem Cell Factor/analysis; Stem Cell Factor/pharmacology; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Hodgkin Disease / Reed-Sternberg Cells / Stem Cell Factor / Proto-Oncogene Proteins c-kit / Fibroblasts Limits: Humans Language: En Journal: Br J Haematol Year: 2002 Type: Article Affiliation country: Italy

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