An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents.

Belenkov, Alexandre I; Paiement, Jean-Pierre; Panasci, Lawrence C; Monia, Brett P; Chow, Terry Y K

Belenkov, Alexandre I; Paiement, Jean-Pierre; Panasci, Lawrence C; Monia, Brett P; Chow, Terry Y K.

Affiliation

Belenkov AI; Department of Oncology, Division of Radiation Oncology, Montreal General Hospital, McGill University, Quebec, H3G 1A4 Canada.

Cancer Res ; 62(20): 5888-96, 2002 Oct 15.

Article in En | MEDLINE | ID: mdl-12384553

Subject(s)

Antigens, Nuclear; Antineoplastic Agents/pharmacology; DNA Helicases; DNA-Binding Proteins/genetics; Glioma/drug therapy; Glioma/radiotherapy; Nuclear Proteins/genetics; Oligonucleotides, Antisense/genetics; Bleomycin/pharmacology; Chlorambucil/pharmacology; Cisplatin/pharmacology; DNA-Activated Protein Kinase; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/biosynthesis; Etoposide/pharmacology; Glioma/genetics; Glioma/metabolism; Humans; Kinetics; Ku Autoantigen; Nuclear Proteins/antagonists & inhibitors; Nuclear Proteins/biosynthesis; Oligonucleotides, Antisense/pharmacology; Protein Serine-Threonine Kinases/metabolism; RNA, Messenger/antagonists & inhibitors; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Substrate Specificity; Transfection; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Nuclear Proteins / Oligonucleotides, Antisense / DNA Helicases / Antigens, Nuclear / DNA-Binding Proteins / Glioma / Antineoplastic Agents Limits: Humans Language: En Journal: Cancer Res Year: 2002 Type: Article

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