The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein.

Giles, Keith M; Daly, John M; Beveridge, Dianne J; Thomson, Andrew M; Voon, Dominic C; Furneaux, Henry M; Jazayeri, Jalal A; Leedman, Peter J

Giles, Keith M; Daly, John M; Beveridge, Dianne J; Thomson, Andrew M; Voon, Dominic C; Furneaux, Henry M; Jazayeri, Jalal A; Leedman, Peter J.

Affiliation

Giles KM; Laboratory for Cancer Medicine and University Department of Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, the University of Western Australia, Perth, Western Australia 6001, Australia.

J Biol Chem ; 278(5): 2937-46, 2003 Jan 31.

Article in En | MEDLINE | ID: mdl-12431987

Subject(s)

3' Untranslated Regions/genetics; Breast Neoplasms/genetics; Cyclins/genetics; Heterogeneous-Nuclear Ribonucleoproteins/metabolism; Poly C/metabolism; RNA, Messenger/genetics; RNA-Binding Proteins/metabolism; Base Sequence; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Epidermal Growth Factor/pharmacology; Female; Gene Expression Regulation, Neoplastic/drug effects; Genes, Reporter; Humans; Kinetics; Luciferases/genetics; Molecular Sequence Data; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Poly C / Breast Neoplasms / RNA, Messenger / RNA-Binding Proteins / Cyclins / 3' Untranslated Regions / Heterogeneous-Nuclear Ribonucleoproteins Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: J Biol Chem Year: 2003 Type: Article Affiliation country: Australia

Search on Google

Add to My VHL

XML

PubMed Links