Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.

Sutherland, Colin J; Alloueche, Ali; Curtis, Jill; Drakeley, Chris J; Ord, Rosalynn; Duraisingh, Manoj; Greenwood, Brian M; Pinder, Margaret; Warhurst, David; Targett, Geoffrey A T

Sutherland, Colin J; Alloueche, Ali; Curtis, Jill; Drakeley, Chris J; Ord, Rosalynn; Duraisingh, Manoj; Greenwood, Brian M; Pinder, Margaret; Warhurst, David; Targett, Geoffrey A T.

Affiliation

Sutherland CJ; Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. colin.sutherland@lshtm.ac.uk

Am J Trop Med Hyg ; 67(6): 578-85, 2002 Dec.

Article in En | MEDLINE | ID: mdl-12518847

Subject(s)

ATP-Binding Cassette Transporters; Antimalarials/therapeutic use; Chloroquine/therapeutic use; Drug Resistance/genetics; Malaria, Falciparum/drug therapy; Plasmodium falciparum/drug effects; Plasmodium falciparum/growth & development; Animals; Anopheles/parasitology; Antimalarials/pharmacology; Chloroquine/pharmacology; DNA, Protozoan/analysis; Gambia; Genotype; Humans; Malaria, Falciparum/parasitology; Membrane Proteins/genetics; Membrane Transport Proteins; Plasmodium falciparum/genetics; Plasmodium falciparum/pathogenicity; Polymerase Chain Reaction; Protozoan Proteins/genetics

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Database: MEDLINE Main subject: Plasmodium falciparum / Drug Resistance / Chloroquine / Malaria, Falciparum / ATP-Binding Cassette Transporters / Antimalarials Type of study: Risk_factors_studies Limits: Animals / Humans Country/Region as subject: Africa Language: En Journal: Am J Trop Med Hyg Year: 2002 Type: Article Affiliation country: United kingdom

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