Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects.

Chen, Xiao-Ping; Tan, Zhi-Rong; Huang, Song-Lin; Huang, Zheng; Ou-Yang, Dong-Sheng; Zhou, Hong-Hao

Chen, Xiao-Ping; Tan, Zhi-Rong; Huang, Song-Lin; Huang, Zheng; Ou-Yang, Dong-Sheng; Zhou, Hong-Hao.

Affiliation

Chen XP; Pharmacogenetics Research Institute, Central South University, Changsha, Hunan 410078, PR China.

Clin Pharmacol Ther ; 73(3): 264-71, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12621391

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Aspirin/pharmacology; Cytochrome P-450 Enzyme System/drug effects; Cytochrome P-450 Enzyme System/metabolism; Mephenytoin/analogs & derivatives; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Anti-Inflammatory Agents, Non-Steroidal/blood; Aryl Hydrocarbon Hydroxylases/metabolism; Asian People/genetics; Aspirin/administration & dosage; Aspirin/blood; Caffeine/blood; China; Chlorzoxazone/blood; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2/metabolism; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP2E1/metabolism; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/genetics; Drug Interactions; Humans; Isoenzymes/metabolism; Male; Mephenytoin/urine; Metoprolol/urine; Midazolam/blood; Mixed Function Oxygenases/metabolism; Oxidoreductases, N-Demethylating/metabolism; Phenotype; Reference Values; Theophylline/blood

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Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Aspirin / Cytochrome P-450 Enzyme System / Mephenytoin Limits: Adult / Humans / Male Country/Region as subject: Asia Language: En Journal: Clin Pharmacol Ther Year: 2003 Type: Article

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