Minimal residual disease prior to stem cell transplant for childhood acute lymphoblastic leukaemia.
Br J Haematol
; 122(1): 24-9, 2003 Jul.
Article
in En
| MEDLINE
| ID: mdl-12823342
ABSTRACT
Allogeneic stem cell transplantation (SCT) is a highly effective therapy for childhood acute lymphoblastic leukaemia (ALL). Concerns about unnecessary toxicity and expense mean that SCT is currently largely reserved for children who cannot be cured with chemotherapy. Not surprisingly, many such children also fail SCT. Retrospective studies have shown that a single analysis of minimal residual disease (MRD) pre-SCT identified those at highest risk of relapse. It is now appropriate to call for the universal incorporation of standardized MRD testing into SCT protocols as the next step to maximize the clinical impact of this technology in ALL.
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Database:
MEDLINE
Main subject:
Hematopoietic Stem Cell Transplantation
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Br J Haematol
Year:
2003
Type:
Article
Affiliation country:
Germany