An autoimmune diabetes locus (Idd21) on mouse chromosome 18.
Mamm Genome
; 14(5): 335-9, 2003 May.
Article
in En
| MEDLINE
| ID: mdl-12856285
ABSTRACT
Twenty-four named Idd loci that contribute to the development of autoimmune diabetes in the nonobese diabetic (NOD) mouse have been mapped by linkage and congenic analysis. Previously, meta-analysis of genome-wide linkage scans supported the existence of a locus for susceptibility to autoimmune phenotypes on rodent Chromosome (Chr) 18, in a position orthologous to the human typc 1 diabetes susceptibility locus IDDM6 (human Chr 18q12-q23). However, an autoimmune diabetes susceptibility locus has not previously been reported on mouse Chr 18. In this study, we demonstrate linkage of the majority of mouse Chr 18 to diabetes in a (ABH x NOD)F1 x NOD backcross. Congenic analysis, introgressing at least 92% of Biozzi ABH Chr 18 onto the NOD background, confirmed the presence of a diabetes locus. The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21.
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Database:
MEDLINE
Main subject:
Chromosome Mapping
/
Chromosomes
/
Genetic Predisposition to Disease
/
Diabetes Mellitus, Type 1
/
Genetic Linkage
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mamm Genome
Journal subject:
GENETICA
Year:
2003
Type:
Article
Affiliation country:
New Zealand