[Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 20(4): 315-7, 2003 Aug.
Article
in Zh
| MEDLINE
| ID: mdl-12903041
ABSTRACT
OBJECTIVE:
To detect the difference between the Chinese Achang and Han ethnic groups in Yunnan province in the distribution of vitamin D receptor (VDR) gene start codon polymorphism.METHODS:
Polymerase chain reaction-restriction fragment length polymorphism, gene sequencing and genetic analysis methods were used. A restriction fragment length polymorphism in the start codon of VDR (Fok I) gene was tested in the Achangs (n=68) and the Hans (n=92).RESULTS:
The frequencies of FF, Ff and ff genotypes were found to be 18%, 35% and 47% in the Achangs, and 22%, 52% and 26% in the Hans, respectively. A significant difference was seen in the frequency distribution of VDR genotype between the Achangs and the Hans(Chi2=7.716, P=0.021).CONCLUSION:
The Achang and Han ethnic groups differ in the frequency distribution of VDR gene start codon polymorphism.
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Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Receptors, Calcitriol
/
Codon, Initiator
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Journal subject:
GENETICA MEDICA
Year:
2003
Type:
Article