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Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide.
Lee, Koo; Park, Cheol Won; Jung, Won-Hyuk; Park, Hee Dong; Lee, Sun Hwa; Chung, Kyung Ha; Park, Su Kyung; Kwon, O Hwan; Kang, Myunggyun; Park, Doo-Hee; Lee, Sang Koo; Kim, Eunice E; Yoon, Suk Kyoon; Kim, Aeri.
Affiliation
  • Lee K; LG Life Sciences Ltd./R&D Park, P.O. Box 61 Yu-Sung, Science Town, Taejon 305-380, Korea. kleec@lgls.co.kr
J Med Chem ; 46(17): 3612-22, 2003 Aug 14.
Article in En | MEDLINE | ID: mdl-12904065
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Database: MEDLINE Main subject: Protease Inhibitors / Sulfanilamides / Thrombin / Dipeptides / Amidines Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Type: Article
Search on Google
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PubMed Links

Database: MEDLINE Main subject: Protease Inhibitors / Sulfanilamides / Thrombin / Dipeptides / Amidines Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Type: Article