Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.
Nature
; 360(6402): 313-9, 1992 Nov 26.
Article
in En
| MEDLINE
| ID: mdl-1448148
ABSTRACT
The inhibins are alphabeta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.
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Database:
MEDLINE
Main subject:
Genes, Tumor Suppressor
/
Gonads
/
Inhibins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Nature
Year:
1992
Type:
Article