Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration.

Nussenblatt, Robert B; Thompson, Darby J S; Li, Zhuqing; Chan, Chi Chao; Peterson, Jan S; Robinson, Randy R; Shames, Richard S; Nagarajan, Sudha; Tang, Meina Tao; Mailman, Michelle; Velez, Gisela; Roy, Chandra; Levy-Clarke, Grace A; Suhler, Eric B; Djalilian, Ali; Sen, Hatice Nida; Al-Khatib, Shadi; Ursea, Roxana; Srivastava, Sunil; Bamji, Allison; Mellow, Susan; Sran, Pushpa; Waldmann, Thomas A; Buggage, Ronald R

Nussenblatt, Robert B; Thompson, Darby J S; Li, Zhuqing; Chan, Chi Chao; Peterson, Jan S; Robinson, Randy R; Shames, Richard S; Nagarajan, Sudha; Tang, Meina Tao; Mailman, Michelle; Velez, Gisela; Roy, Chandra; Levy-Clarke, Grace A; Suhler, Eric B; Djalilian, Ali; Sen, Hatice Nida; Al-Khatib, Shadi; Ursea, Roxana; Srivastava, Sunil; Bamji, Allison; Mellow, Susan; Sran, Pushpa; Waldmann, Thomas A; Buggage, Ronald R.

Affiliation

Nussenblatt RB; The National Eye Institute, Laboratory of Immunology, NIH, Building 10, 10 Center Drive, Bethesda, MD, USA. DrBob@nei.nih.gov

J Autoimmun ; 21(3): 283-93, 2003 Nov.

Article in En | MEDLINE | ID: mdl-14599854

Subject(s)

Antibodies, Monoclonal/therapeutic use; Immunoglobulin G/therapeutic use; Immunosuppressive Agents/therapeutic use; Uveitis/drug therapy; Adolescent; Adult; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/blood; Antibodies, Monoclonal, Humanized; Antigens, CD/analysis; Apoptosis/drug effects; Autoimmune Diseases/drug therapy; Daclizumab; Female; Flow Cytometry; Humans; Immunoglobulin G/administration & dosage; Immunoglobulin G/blood; Immunohistochemistry; Immunosuppressive Agents/administration & dosage; Immunosuppressive Agents/blood; Infusions, Intravenous; Injections, Subcutaneous; Interleukin-2 Receptor alpha Subunit; Lymph Nodes/chemistry; Male; Middle Aged; Patient Selection; Receptors, Interleukin/immunology; Receptors, Interleukin-2/analysis; Receptors, Interleukin-2/immunology; T-Lymphocytes/chemistry; T-Lymphocytes/immunology; Treatment Outcome; Visual Acuity/drug effects

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Uveitis / Immunoglobulin G / Immunosuppressive Agents / Antibodies, Monoclonal Type of study: Clinical_trials Language: En Journal: J Autoimmun Journal subject: ALERGIA E IMUNOLOGIA Year: 2003 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links