Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.

Sun, Jiuru; Bird, Catherina H; Thia, Kevin Y; Matthews, Antony Y; Trapani, Joseph A; Bird, Phillip I

Sun, Jiuru; Bird, Catherina H; Thia, Kevin Y; Matthews, Antony Y; Trapani, Joseph A; Bird, Phillip I.

Affiliation

Sun J; Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Victoria, Australia.

J Biol Chem ; 279(17): 16907-11, 2004 Apr 23.

Article in En | MEDLINE | ID: mdl-14752093

Subject(s)

Alleles; Apoptosis; Serine Endopeptidases/biosynthesis; Amino Acids; Animals; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins/chemistry; Caspase 3; Caspases/metabolism; Dose-Response Relationship, Drug; Granzymes; Heterozygote; Homozygote; Humans; K562 Cells; Killer Cells, Lymphokine-Activated/metabolism; Kinetics; Lymphocytes/metabolism; Mice; Pichia/metabolism; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Protease Inhibitors/pharmacology; Recombinant Proteins/chemistry; Serine Endopeptidases/genetics; Time Factors

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Database: MEDLINE Main subject: Serine Endopeptidases / Apoptosis / Alleles Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2004 Type: Article Affiliation country: Australia

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