Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.

Beyer, Thomas P; Schmidt, Robert J; Foxworthy, Patricia; Zhang, Youyan; Dai, Jiannong; Bensch, William R; Kauffman, Raymond F; Gao, Hong; Ryan, Timothy P; Jiang, Xian-Cheng; Karathanasis, Sotirios K; Eacho, Patrick I; Cao, Guoqing

Beyer, Thomas P; Schmidt, Robert J; Foxworthy, Patricia; Zhang, Youyan; Dai, Jiannong; Bensch, William R; Kauffman, Raymond F; Gao, Hong; Ryan, Timothy P; Jiang, Xian-Cheng; Karathanasis, Sotirios K; Eacho, Patrick I; Cao, Guoqing.

Affiliation

Beyer TP; Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285, USA.

J Pharmacol Exp Ther ; 309(3): 861-8, 2004 Jun.

Article in En | MEDLINE | ID: mdl-14960661

Subject(s)

Anticholesteremic Agents/pharmacology; Lipoproteins, HDL/metabolism; Liver/drug effects; Phospholipid Transfer Proteins; Receptors, Cytoplasmic and Nuclear/agonists; Receptors, Cytoplasmic and Nuclear/metabolism; Transcription Factors/agonists; Triglycerides/metabolism; Animals; Carrier Proteins/metabolism; DNA-Binding Proteins; Hydrocarbons, Fluorinated; Liver/metabolism; Liver X Receptors; Membrane Proteins/metabolism; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Pyrimidines/pharmacology; Sulfonamides

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Database: MEDLINE Main subject: Transcription Factors / Triglycerides / Receptors, Cytoplasmic and Nuclear / Phospholipid Transfer Proteins / Lipoproteins, HDL / Liver / Anticholesteremic Agents Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2004 Type: Article Affiliation country: United States

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