4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies.

Altmann, Karl-Heinz; Flörsheimer, Andreas; O'Reilly, Terence; Wartmann, Markus

Altmann, Karl-Heinz; Flörsheimer, Andreas; O'Reilly, Terence; Wartmann, Markus.

Affiliation

Altmann KH; Novartis Institutes for Biomedical Research, Novartis Pharma AG, Corporate Research, CH-4002 Basel, WKL-136.5.22, Switzerland.

Prog Med Chem ; 42: 171-205, 2004.

Article in En | MEDLINE | ID: mdl-15003721

Subject(s)

Antineoplastic Agents/pharmacology; Epothilones/pharmacology; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/metabolism; Epothilones/chemical synthesis; Epothilones/metabolism; Humans; Microtubules/drug effects; Microtubules/metabolism; Neoplasms/drug therapy; Neoplasms/metabolism; Structure-Activity Relationship; Tubulin/metabolism

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Database: MEDLINE Main subject: Epothilones / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Prog Med Chem Year: 2004 Type: Article Affiliation country: Switzerland

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