Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.

Robben, Paul M; Mordue, Dana G; Truscott, Steven M; Takeda, Kiyoshi; Akira, Shizuo; Sibley, L David

Robben, Paul M; Mordue, Dana G; Truscott, Steven M; Takeda, Kiyoshi; Akira, Shizuo; Sibley, L David.

Affiliation

Robben PM; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

J Immunol ; 172(6): 3686-94, 2004 Mar 15.

Article in En | MEDLINE | ID: mdl-15004172

Subject(s)

Interleukin-12/biosynthesis; Macrophages/immunology; Macrophages/parasitology; Toxoplasma/genetics; Toxoplasma/immunology; Adaptor Proteins, Signal Transducing; Animals; Antigens, Differentiation/genetics; Antigens, Differentiation/physiology; Cell Nucleus/metabolism; Dose-Response Relationship, Immunologic; Female; Genotype; Interleukin-12/antagonists & inhibitors; Kinetics; Macrophages/metabolism; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; NF-kappa B/metabolism; Receptors, Immunologic/deficiency; Receptors, Immunologic/genetics; Receptors, Immunologic/physiology; Species Specificity; Toxoplasma/pathogenicity; Virulence/genetics

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Database: MEDLINE Main subject: Toxoplasma / Interleukin-12 / Macrophages Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2004 Type: Article Affiliation country: United States

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