Analysis of chromosomes 3, 7, X and the EGFR gene in uterine cervical cancer progression.
Eur J Cancer
; 40(10): 1624-9, 2004 Jul.
Article
in En
| MEDLINE
| ID: mdl-15196550
ABSTRACT
The aim of this study was to investigate the possible role of genetic alterations in the genesis and progression of cervical carcinomas. We analysed the 3, 7, X aneusomy of chromosomes and the status of the epidermal growth factor receptor (EGFR) gene by fluorescence in situ hybridisation (FISH) analysis. Polysomy of chromosomes 3 and X defined the transition from high-grade squamous intraepithelium lesions (HSIL) to cervical carcinoma. Chromosome 7 monosomy and polysomy did not show any statistical significant differences between the groups examined. When we compared the chromosomal aneusomies in all of the specimens using the Kruskal-Wallis test, significant differences (P = 0.0001, P = 0.0001 for chromosomes 3 and X, respectively) were observed. Using a ratio of the EGFR gene signals and chromosome 7 centromeric signals, no samples showed gene amplification. Our results demonstrate the importance of chromosomal 3 and X aneusomies in the development and progression from HSIL to cervical carcinoma, highlighting their usefulness as genetic markers for identifying SILs at high-risk of progression.
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Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 3
/
Chromosomes, Human, Pair 7
/
Uterine Cervical Neoplasms
/
Chromosome Aberrations
/
Chromosomes, Human, X
/
ErbB Receptors
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Eur J Cancer
Year:
2004
Type:
Article
Affiliation country:
Italy