Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

Xu, Bin; Hu, Shi-Quan; Chu, Ying-Chi; Huang, Kun; Nakagawa, Satoe H; Whittaker, Jonathan; Katsoyannis, Panayotis G; Weiss, Michael A

Xu, Bin; Hu, Shi-Quan; Chu, Ying-Chi; Huang, Kun; Nakagawa, Satoe H; Whittaker, Jonathan; Katsoyannis, Panayotis G; Weiss, Michael A.

Affiliation

Xu B; Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4935, USA.

Biochemistry ; 43(26): 8356-72, 2004 Jul 06.

Article in En | MEDLINE | ID: mdl-15222748

Subject(s)

Diabetes Mellitus/genetics; Insulin/genetics; Receptor, Insulin/chemistry; Amino Acid Sequence; Animals; Azides/chemistry; Blotting, Western; CHO Cells; Chymotrypsin/chemistry; Cricetinae; Cross-Linking Reagents/pharmacology; Dimerization; Disulfides; Exons; Humans; Insulin/metabolism; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutation; Phenylalanine/analogs & derivatives; Phenylalanine/chemistry; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Trypsin/chemistry; Ultraviolet Rays

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Database: MEDLINE Main subject: Receptor, Insulin / Diabetes Mellitus / Insulin Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Biochemistry Year: 2004 Type: Article Affiliation country: United States

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