Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat.
FEBS Lett
; 569(1-3): 245-8, 2004 Jul 02.
Article
in En
| MEDLINE
| ID: mdl-15225642
ABSTRACT
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that promotes catabolic and inhibits anabolic pathways. However, the role of AMPK in adipocytes is poorly understood. We show that transgenic expression of mitochondrial uncoupling protein 1 in white fat, which induces obesity resistance in mice, is associated with depression of cellular energy charge, activation of AMPK, downregulation of adipogenic genes, and increase in lipid oxidation. Activation of AMPK may explain the complex metabolic changes in adipose tissue of these animals and our results support a role for adipocyte AMPK in the regulation of storage of body fat.
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Database:
MEDLINE
Main subject:
Carrier Proteins
/
Adenylate Kinase
/
Adipose Tissue
/
Membrane Proteins
/
Obesity
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
2004
Type:
Article
Affiliation country:
Czech Republic