Novel glycine transporter type-2 reuptake inhibitors. Part 2: beta- and gamma-amino acid derivatives.

Wolin, Ronald L; Santillán, Alejandro; Barclay, Tristin; Tang, Liu; Venkatesan, Hariharan; Wilson, Sandy; Lee, Doo Hyun; Lovenberg, Timothy W

Wolin, Ronald L; Santillán, Alejandro; Barclay, Tristin; Tang, Liu; Venkatesan, Hariharan; Wilson, Sandy; Lee, Doo Hyun; Lovenberg, Timothy W.

Affiliation

Wolin RL; Johnson & Johnson Pharmaceutical Research and Development, LLC, 3210 Merryfield Row, San Diego, CA 92121, USA. rwolin@prdus.jnj.com

Bioorg Med Chem ; 12(16): 4493-509, 2004 Aug 15.

Article in En | MEDLINE | ID: mdl-15265499

Subject(s)

Amino Acid Transport Systems, Neutral/antagonists & inhibitors; Amino Acids/chemistry; Amino Acids/pharmacology; Neurotransmitter Uptake Inhibitors/chemistry; Neurotransmitter Uptake Inhibitors/pharmacology; Amino Acid Transport Systems, Neutral/genetics; Amino Acids/chemical synthesis; Animals; Biological Transport/drug effects; COS Cells; Chlorocebus aethiops; Glycine/metabolism; Glycine Plasma Membrane Transport Proteins; Guanidines/chemistry; Neurotransmitter Uptake Inhibitors/chemical synthesis

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Database: MEDLINE Main subject: Neurotransmitter Uptake Inhibitors / Amino Acid Transport Systems, Neutral / Amino Acids Limits: Animals Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2004 Type: Article Affiliation country: United States

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