Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression.

Siwkowski, Andrew M; Madge, Lisa A; Koo, Seongjoon; McMillan, Erin L; Monia, Brett P; Pober, Jordan S; Baker, Brenda F

Siwkowski, Andrew M; Madge, Lisa A; Koo, Seongjoon; McMillan, Erin L; Monia, Brett P; Pober, Jordan S; Baker, Brenda F.

Affiliation

Siwkowski AM; Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA.

Mol Pharmacol ; 66(3): 572-9, 2004 Sep.

Article in En | MEDLINE | ID: mdl-15322249

Subject(s)

Endothelium, Vascular/drug effects; Gene Expression/drug effects; Oligonucleotides, Antisense/pharmacology; Proteins/antagonists & inhibitors; Tumor Necrosis Factor-alpha/pharmacology; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular/metabolism; Humans; Intercellular Adhesion Molecule-1/metabolism; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Oligonucleotide Array Sequence Analysis; Proteins/genetics; Receptors, Tumor Necrosis Factor/metabolism; TNF Receptor-Associated Factor 1

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Database: MEDLINE Main subject: Endothelium, Vascular / Proteins / Gene Expression / Oligonucleotides, Antisense / Tumor Necrosis Factor-alpha Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Mol Pharmacol Year: 2004 Type: Article Affiliation country: United States

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