Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.

Yang, Hsiu-Chiung; Chai, Xiyun; Mosior, Marian; Kohn, Wayne; Boggs, Leonard N; Erickson, Jon A; McClure, Don B; Yeh, Wu-Kuang; Zhang, Lianshen; Gonzalez-DeWhitt, Patricia; Mayer, John P; Martin, Jose Alfredo; Hu, Jingdan; Chen, Shu-Hui; Bueno, Ana Belen; Little, Sheila P; McCarthy, James R; May, Patrick C

Yang, Hsiu-Chiung; Chai, Xiyun; Mosior, Marian; Kohn, Wayne; Boggs, Leonard N; Erickson, Jon A; McClure, Don B; Yeh, Wu-Kuang; Zhang, Lianshen; Gonzalez-DeWhitt, Patricia; Mayer, John P; Martin, Jose Alfredo; Hu, Jingdan; Chen, Shu-Hui; Bueno, Ana Belen; Little, Sheila P; McCarthy, James R; May, Patrick C.

Affiliation

Yang HC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. Ginnie_Yang@Lilly.com

J Neurochem ; 91(6): 1249-59, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15584902

Subject(s)

Aspartic Acid Endopeptidases/chemistry; Aspartic Acid Endopeptidases/genetics; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases/antagonists & inhibitors; Aspartic Acid Endopeptidases/metabolism; Cell Line; Endopeptidases; Guinea Pigs; Humans; Kinetics; Mice; Molecular Conformation; Molecular Sequence Data; Recombinant Proteins/antagonists & inhibitors; Species Specificity

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Database: MEDLINE Main subject: Aspartic Acid Endopeptidases Limits: Animals / Humans Language: En Journal: J Neurochem Year: 2004 Type: Article Affiliation country: United States

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