PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways.

Grandage, V L; Gale, R E; Linch, D C; Khwaja, A

Grandage, V L; Gale, R E; Linch, D C; Khwaja, A.

Affiliation

Grandage VL; Royal Free and University College London Medical School, Department of Haematology, 98 Chenies Mews, London, UK. vlg@talk21.com

Leukemia ; 19(4): 586-94, 2005 Apr.

Article in En | MEDLINE | ID: mdl-15703783

Subject(s)

Leukemia, Myeloid/metabolism; MAP Kinase Signaling System/physiology; NF-kappa B/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; ADP-ribosyl Cyclase/metabolism; ADP-ribosyl Cyclase 1; Acute Disease; Animals; Antigens, CD/metabolism; Antigens, CD34/metabolism; Antimetabolites, Antineoplastic/pharmacology; Cell Survival/physiology; Chromones/pharmacology; Cytarabine/pharmacology; Drug Resistance, Neoplasm; Enzyme Inhibitors/pharmacology; Humans; Leukemia, Myeloid/drug therapy; Leukemia, Myeloid/pathology; MAP Kinase Signaling System/drug effects; Membrane Glycoproteins; Morpholines/pharmacology; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Leukemia, Myeloid / NF-kappa B / Tumor Suppressor Protein p53 / Proto-Oncogene Proteins / Protein Serine-Threonine Kinases / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2005 Type: Article Affiliation country: United kingdom

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