Adaptor Proteins, Vesicular Transport/metabolism; Antigens, Differentiation/metabolism; MAP Kinase Signaling System/physiology; Membrane Glycoproteins/metabolism; Receptors, Cell Surface/metabolism; Receptors, Immunologic/metabolism; Vaccinia virus/metabolism; Viral Proteins/metabolism; ATP-Binding Cassette Transporters; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cell Line; DNA-Binding Proteins/metabolism; Disease Models, Animal; Gene Expression Regulation, Viral/genetics; Gene Expression Regulation, Viral/physiology; Humans; Interferon Regulatory Factor-3; Interferon-beta/biosynthesis; Lymphocyte Activation/genetics; Lymphocyte Activation/physiology; MAP Kinase Signaling System/genetics; Mice; Molecular Sequence Data; Myeloid Differentiation Factor 88; Periplasmic Binding Proteins; Protein Structure, Tertiary/genetics; Protein Structure, Tertiary/physiology; T-Lymphocytes/physiology; Toll-Like Receptor 3; Toll-Like Receptor 4; Toll-Like Receptors; Transcription Factors/metabolism; Vaccinia virus/genetics; Vaccinia virus/pathogenicity; Viral Proteins/genetics; Virus Diseases/genetics; Virus Diseases/physiopathology; Virus Replication/genetics; Virus Replication/physiology