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In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo, Michael J; Almond, Harold R; Hecker, Leonard R; Schott, Mary R; Yabut, Stephen C; Zhang, Han-Cheng; Andrade-Gordon, Patricia; Corcoran, Thomas W; Giardino, Edward C; Kauffman, Jack A; Lewis, Joan M; de Garavilla, Lawrence; Haertlein, Barbara J; Maryanoff, Bruce E.
Affiliation
  • Costanzo MJ; Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776, USA.
J Med Chem ; 48(6): 1984-2008, 2005 Mar 24.
Article in En | MEDLINE | ID: mdl-15771442
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Database: MEDLINE Main subject: Oligopeptides / Thiazoles / Thrombin / Fibrinolytic Agents / Ketones / Anticoagulants Type of study: Prognostic_studies Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States
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PubMed Links

Database: MEDLINE Main subject: Oligopeptides / Thiazoles / Thrombin / Fibrinolytic Agents / Ketones / Anticoagulants Type of study: Prognostic_studies Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2005 Type: Article Affiliation country: United States