Enhanced apoptosis and tumor regression induced by a direct agonist antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2.

Motoki, Kazuhiro; Mori, Eiji; Matsumoto, Atsushi; Thomas, Mayumi; Tomura, Takafumi; Humphreys, Robin; Albert, Vivian; Muto, Mari; Yoshida, Hitoshi; Aoki, Masami; Tamada, Taro; Kuroki, Ryota; Yoshida, Hideaki; Ishida, Isao; Ware, Carl F; Kataoka, Shiro

Motoki, Kazuhiro; Mori, Eiji; Matsumoto, Atsushi; Thomas, Mayumi; Tomura, Takafumi; Humphreys, Robin; Albert, Vivian; Muto, Mari; Yoshida, Hitoshi; Aoki, Masami; Tamada, Taro; Kuroki, Ryota; Yoshida, Hideaki; Ishida, Isao; Ware, Carl F; Kataoka, Shiro.

Affiliation

Motoki K; Pharmaceutical Research Laboratories, Kirin Brewery Co., Ltd., Gunma, Japan.

Clin Cancer Res ; 11(8): 3126-35, 2005 Apr 15.

Article in En | MEDLINE | ID: mdl-15837769

Subject(s)

Antibodies, Monoclonal/pharmacology; Apoptosis/drug effects; Receptors, Tumor Necrosis Factor/immunology; Xenograft Model Antitumor Assays/methods; Animals; Antibody Specificity; Cell Line, Tumor; Cell Survival/drug effects; Dimerization; Dose-Response Relationship, Drug; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor/chemistry; Remission Induction

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Database: MEDLINE Main subject: Apoptosis / Receptors, Tumor Necrosis Factor / Xenograft Model Antitumor Assays / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: Japan

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