Role of human liver cytochrome P450 2C9 in the metabolism of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.

Tsuda-Tsukimoto, Minoru; Ogasawara, Yuko; Kume, Toshiyuki

Tsuda-Tsukimoto, Minoru; Ogasawara, Yuko; Kume, Toshiyuki.

Affiliation

Tsuda-Tsukimoto M; Exploratory DMPK, Exploratory Toxicology & DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama 33508505, Japan. m-tsuda@tanabe.co.jp

Drug Metab Pharmacokinet ; 20(2): 127-34, 2005 Apr.

Article in En | MEDLINE | ID: mdl-15855725

Subject(s)

Aryl Hydrocarbon Hydroxylases/physiology; Integrin alpha4beta1/antagonists & inhibitors; Integrins/antagonists & inhibitors; Microsomes, Liver/enzymology; Phenylalanine/analogs & derivatives; Phenylalanine/pharmacokinetics; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Aryl Hydrocarbon Hydroxylases/genetics; Cytochrome P-450 CYP2C9; Humans; In Vitro Techniques; Isoenzymes/physiology; Polymorphism, Genetic; Recombinant Proteins/metabolism

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Database: MEDLINE Main subject: Phenylalanine / Microsomes, Liver / Aryl Hydrocarbon Hydroxylases / Integrins / Integrin alpha4beta1 Limits: Humans Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2005 Type: Article Affiliation country: Japan

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