A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol.

Shah, Manish A; Kortmansky, Jeremy; Motwani, Monica; Drobnjak, Marija; Gonen, Mithat; Yi, Sandy; Weyerbacher, Amanda; Cordon-Cardo, Carlos; Lefkowitz, Robert; Brenner, Baruch; O'Reilly, Eileen; Saltz, Leonard; Tong, William; Kelsen, David P; Schwartz, Gary K

Shah, Manish A; Kortmansky, Jeremy; Motwani, Monica; Drobnjak, Marija; Gonen, Mithat; Yi, Sandy; Weyerbacher, Amanda; Cordon-Cardo, Carlos; Lefkowitz, Robert; Brenner, Baruch; O'Reilly, Eileen; Saltz, Leonard; Tong, William; Kelsen, David P; Schwartz, Gary K.

Affiliation

Shah MA; Department of Medicine, Division of Solid Tumor Oncology, Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Clin Cancer Res ; 11(10): 3836-45, 2005 May 15.

Article in En | MEDLINE | ID: mdl-15897584

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Camptothecin/analogs & derivatives; Neoplasms/drug therapy; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Bilirubin/analysis; Camptothecin/administration & dosage; Camptothecin/adverse effects; Camptothecin/pharmacokinetics; Cell Cycle Proteins/biosynthesis; Cyclin-Dependent Kinase Inhibitor p21; Drug Administration Schedule; Drug Interactions; Female; Flavonoids/administration & dosage; Flavonoids/adverse effects; Flavonoids/pharmacokinetics; Humans; Intracellular Signaling Peptides and Proteins; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Piperidines/administration & dosage; Piperidines/adverse effects; Piperidines/pharmacokinetics; Treatment Outcome; Tumor Suppressor Protein p53/biosynthesis

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Database: MEDLINE Main subject: Camptothecin / Antineoplastic Combined Chemotherapy Protocols / Neoplasms Type of study: Prognostic_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2005 Type: Article Affiliation country: United States

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