3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells.

Pae, Hyun-Ock; Oh, Gi-Su; Lee, Bok-Soo; Rim, Joung-Sik; Kim, Young-Myeong; Chung, Hun-Taeg

Pae, Hyun-Ock; Oh, Gi-Su; Lee, Bok-Soo; Rim, Joung-Sik; Kim, Young-Myeong; Chung, Hun-Taeg.

Affiliation

Pae HO; Medicinal Resources Research Institute and Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbug 570-749, Republic of Korea.

Atherosclerosis ; 187(2): 274-84, 2006 Aug.

Article in En | MEDLINE | ID: mdl-16246346

Subject(s)

3-Hydroxyanthranilic Acid/pharmacology; Chemokine CCL2/metabolism; Endothelium, Vascular/drug effects; Free Radical Scavengers/pharmacology; Heme Oxygenase-1/genetics; Vascular Cell Adhesion Molecule-1/genetics; 3-Hydroxyanthranilic Acid/metabolism; Antioxidants/metabolism; Atherosclerosis/immunology; Atherosclerosis/metabolism; Bilirubin/metabolism; Bilirubin/pharmacology; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Free Radical Scavengers/metabolism; Gene Expression Regulation, Enzymologic/drug effects; Heme Oxygenase-1/metabolism; Humans; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Response Elements/physiology; Tryptophan/metabolism; Tumor Necrosis Factor-alpha/metabolism; Umbilical Veins/cytology; Vascular Cell Adhesion Molecule-1/metabolism

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Database: MEDLINE Main subject: Endothelium, Vascular / Free Radical Scavengers / Vascular Cell Adhesion Molecule-1 / Chemokine CCL2 / Heme Oxygenase-1 / 3-Hydroxyanthranilic Acid Limits: Humans Language: En Journal: Atherosclerosis Year: 2006 Type: Article

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