Okadaic acid induces JNK activation, bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons.

Yoon, SeungYong; Choi, JungEun; Yoon, JuHee; Huh, Jae-Wan; Kim, DongHou

Yoon, SeungYong; Choi, JungEun; Yoon, JuHee; Huh, Jae-Wan; Kim, DongHou.

Affiliation

Yoon S; Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, 388-1 PoongNap-Dong, SongPa-Gu, Seoul 138-736, Korea.

Neurosci Lett ; 394(3): 190-5, 2006 Feb 20.

Article in En | MEDLINE | ID: mdl-16260088

Subject(s)

Apoptosis Regulatory Proteins/biosynthesis; Enzyme Inhibitors/pharmacology; MAP Kinase Kinase 4/metabolism; Membrane Proteins/biosynthesis; Mitochondria/metabolism; Neurons/metabolism; Okadaic Acid/toxicity; Proto-Oncogene Proteins/biosynthesis; Animals; Bcl-2-Like Protein 11; Blotting, Western; Caspase 3; Caspases/biosynthesis; Cells, Cultured; Enzyme Activation/drug effects; Membrane Potentials/drug effects; Mitochondria/drug effects; Mitochondria/pathology; Nerve Degeneration/chemically induced; Nerve Degeneration/pathology; Neurons/drug effects; Neurons/pathology; Rats; bcl-2 Homologous Antagonist-Killer Protein/biosynthesis; bcl-2-Associated X Protein/biosynthesis; bcl-Associated Death Protein/biosynthesis; p38 Mitogen-Activated Protein Kinases/biosynthesis; p38 Mitogen-Activated Protein Kinases/genetics

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Database: MEDLINE Main subject: Proto-Oncogene Proteins / Okadaic Acid / MAP Kinase Kinase 4 / Enzyme Inhibitors / Apoptosis Regulatory Proteins / Membrane Proteins / Mitochondria / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurosci Lett Year: 2006 Type: Article

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