Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties.

Wendt, John A; Wu, Hongwei; Stenmark, Heather G; Boys, Mark L; Downs, Victoria L; Penning, Thomas D; Chen, Barbara B; Wang, Yaping; Duffin, Tiffany; Finn, Mary Beth; Keene, Jeffery L; Engleman, V Wayne; Freeman, Sandra K; Hanneke, Melanie L; Shannon, Kristen E; Nickols, Maureen A; Steininger, Christina N; Westlin, Marissa; Klover, Jon A; Westlin, William; Nickols, G Allen; Russell, Mark A

Wendt, John A; Wu, Hongwei; Stenmark, Heather G; Boys, Mark L; Downs, Victoria L; Penning, Thomas D; Chen, Barbara B; Wang, Yaping; Duffin, Tiffany; Finn, Mary Beth; Keene, Jeffery L; Engleman, V Wayne; Freeman, Sandra K; Hanneke, Melanie L; Shannon, Kristen E; Nickols, Maureen A; Steininger, Christina N; Westlin, Marissa; Klover, Jon A; Westlin, William; Nickols, G Allen; Russell, Mark A.

Affiliation

Wendt JA; Department of Medicinal Chemistry, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. john.a.wendt@pfizer.com

Bioorg Med Chem Lett ; 16(4): 845-9, 2006 Feb 15.

Article in En | MEDLINE | ID: mdl-16303301

Subject(s)

Butyrates/chemical synthesis; Butyrates/pharmacokinetics; Integrin alphaVbeta3/antagonists & inhibitors; Thiazoles/chemical synthesis; Thiazoles/pharmacokinetics; Administration, Oral; Animals; Antigens, Neoplasm; Biological Availability; Butyrates/administration & dosage; Dogs; Drug Evaluation, Preclinical; Haplorhini; Integrins/antagonists & inhibitors; Molecular Structure; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors; Rats; Structure-Activity Relationship; Thiazoles/administration & dosage

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Database: MEDLINE Main subject: Thiazoles / Butyrates / Integrin alphaVbeta3 Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Type: Article Affiliation country: United States

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