Importance of within subject variation in levodopa pharmacokinetics: a 4 year cohort study in Parkinson's disease.

Chan, Phylinda L S; Nutt, John G; Holford, Nicholas H G

Chan, Phylinda L S; Nutt, John G; Holford, Nicholas H G.

Affiliation

Chan PL; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand. Phylinda.Chan@pfizer.com

J Pharmacokinet Pharmacodyn ; 32(3-4): 307-31, 2005 Aug.

Article in En | MEDLINE | ID: mdl-16320098

Subject(s)

Dopamine Agents/pharmacokinetics; Levodopa/pharmacokinetics; Parkinson Disease/drug therapy; Administration, Oral; Adult; Aged; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa/administration & dosage; Carbidopa/therapeutic use; Clinical Trials as Topic; Cohort Studies; Computer Simulation; Dopa Decarboxylase/metabolism; Dopamine Agents/administration & dosage; Dopamine Agents/therapeutic use; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/therapeutic use; Female; Humans; Infusions, Intravenous; Levodopa/administration & dosage; Levodopa/therapeutic use; Longitudinal Studies; Male; Middle Aged; Models, Biological; Parkinson Disease/blood; Parkinson Disease/metabolism

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Database: MEDLINE Main subject: Parkinson Disease / Dopamine Agents / Levodopa Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: J Pharmacokinet Pharmacodyn Journal subject: FARMACOLOGIA Year: 2005 Type: Article Affiliation country: New Zealand

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