Administration of baclofen, a gamma-aminobutyric acid type B agonist in the thalamic ventrobasal complex, attenuates allodynia in monoarthritic rats subjected to the ankle-bend test.

Potes, Catarina Soares; Neto, Fani Lourença; Castro-Lopes, José Manuel

Potes, Catarina Soares; Neto, Fani Lourença; Castro-Lopes, José Manuel.

Affiliation

Potes CS; Institute of Histology and Embryology, Faculty of Medicine and IBMC, University of Porto, Porto, Portugal.

J Neurosci Res ; 83(3): 515-23, 2006 Feb 15.

Article in En | MEDLINE | ID: mdl-16400658

Subject(s)

Ankle Joint/drug effects; Baclofen/administration & dosage; GABA-B Receptor Agonists; Metatarsalgia/drug therapy; Thalamus/drug effects; Animals; Ankle Joint/physiopathology; Arthritis, Experimental/chemically induced; Arthritis, Experimental/complications; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Inflammation/drug therapy; Inflammation/etiology; Male; Metatarsalgia/etiology; Pain Measurement/methods; Rats; Rats, Wistar; Time Factors

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Database: MEDLINE Main subject: Thalamus / Baclofen / Metatarsalgia / GABA-B Receptor Agonists / Ankle Joint Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: J Neurosci Res Year: 2006 Type: Article Affiliation country: Portugal

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