A QSAR model for in silico screening of MAO-A inhibitors. Prediction, synthesis, and biological assay of novel coumarins.

Santana, Lourdes; Uriarte, Eugenio; González-Díaz, Humberto; Zagotto, Giuseppe; Soto-Otero, Ramón; Méndez-Alvarez, Estefanía

Santana, Lourdes; Uriarte, Eugenio; González-Díaz, Humberto; Zagotto, Giuseppe; Soto-Otero, Ramón; Méndez-Alvarez, Estefanía.

Affiliation

Santana L; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15872 Santiago de Compostela, Spain. qolsant@usc.es

J Med Chem ; 49(3): 1149-56, 2006 Feb 09.

Article in En | MEDLINE | ID: mdl-16451079

Subject(s)

Coumarins/chemistry; Monoamine Oxidase Inhibitors/chemistry; Monoamine Oxidase/chemistry; Quantitative Structure-Activity Relationship; Algorithms; Animals; Brain/drug effects; Brain/enzymology; Coumarins/chemical synthesis; Coumarins/pharmacology; In Vitro Techniques; Isoenzymes/antagonists & inhibitors; Isoenzymes/chemistry; Male; Markov Chains; Mitochondria/drug effects; Mitochondria/enzymology; Models, Molecular; Monoamine Oxidase Inhibitors/chemical synthesis; Monoamine Oxidase Inhibitors/pharmacology; Rats; Rats, Sprague-Dawley

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Database: MEDLINE Main subject: Coumarins / Quantitative Structure-Activity Relationship / Monoamine Oxidase / Monoamine Oxidase Inhibitors Type of study: Diagnostic_studies / Health_economic_evaluation / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Type: Article Affiliation country: Spain

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