Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A.

Pérez, Leonardo M; Milkiewicz, Piotr; Elias, Elwyn; Coleman, Roger; Sánchez Pozzi, Enrique J; Roma, Marcelo G

Pérez, Leonardo M; Milkiewicz, Piotr; Elias, Elwyn; Coleman, Roger; Sánchez Pozzi, Enrique J; Roma, Marcelo G.

Affiliation

Pérez LM; Institute of Experimental Physiology, CONICET-National University of Rosario, Rosario, Argentina.

Toxicol Sci ; 91(1): 150-8, 2006 May.

Article in En | MEDLINE | ID: mdl-16452108

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Bile Acids and Salts/metabolism; Cyclic AMP-Dependent Protein Kinases/metabolism; Hepatocytes/metabolism; Oxidative Stress; Protein Kinase C/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 11; Animals; Bucladesine/pharmacology; Calcium/metabolism; Enzyme Activation; Hepatocytes/enzymology; Male; Naphthoquinones/pharmacology; Protein Kinase C/antagonists & inhibitors; Rats; Rats, Wistar; tert-Butylhydroperoxide/pharmacology

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Database: MEDLINE Main subject: Protein Kinase C / Bile Acids and Salts / Cyclic AMP-Dependent Protein Kinases / Oxidative Stress / ATP-Binding Cassette Transporters / Hepatocytes Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2006 Type: Article Affiliation country: Argentina

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