Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox.

Nobuhisa, Ikuo; Takeya, Ryu; Ogura, Kenji; Ueno, Noriko; Kohda, Daisuke; Inagaki, Fuyuhiko; Sumimoto, Hideki

Nobuhisa, Ikuo; Takeya, Ryu; Ogura, Kenji; Ueno, Noriko; Kohda, Daisuke; Inagaki, Fuyuhiko; Sumimoto, Hideki.

Affiliation

Nobuhisa I; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.

Biochem J ; 396(1): 183-92, 2006 May 15.

Article in En | MEDLINE | ID: mdl-16460309

Subject(s)

NADPH Oxidases/physiology; src Homology Domains; Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Humans; Mutagenesis, Site-Directed; NADPH Oxidases/chemistry; Phagocytes/enzymology; Protein Binding; Protein Interaction Mapping; Protein Structure, Secondary; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/physiology; Structure-Activity Relationship; Superoxides/metabolism; Transfection

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Full text: 1 Database: MEDLINE Main subject: Src Homology Domains / NADPH Oxidases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem J Year: 2006 Type: Article Affiliation country: Japan

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