Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

Fiedler, Ulrike; Reiss, Yvonne; Scharpfenecker, Marion; Grunow, Verena; Koidl, Stefanie; Thurston, Gavin; Gale, Nicholas W; Witzenrath, Martin; Rosseau, Simone; Suttorp, Norbert; Sobke, Astrid; Herrmann, Matthias; Preissner, Klaus T; Vajkoczy, Peter; Augustin, Hellmut G

Fiedler, Ulrike; Reiss, Yvonne; Scharpfenecker, Marion; Grunow, Verena; Koidl, Stefanie; Thurston, Gavin; Gale, Nicholas W; Witzenrath, Martin; Rosseau, Simone; Suttorp, Norbert; Sobke, Astrid; Herrmann, Matthias; Preissner, Klaus T; Vajkoczy, Peter; Augustin, Hellmut G.

Affiliation

Fiedler U; Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany.

Nat Med ; 12(2): 235-9, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16462802

Subject(s)

Angiopoietin-2/physiology; Inflammation/etiology; Tumor Necrosis Factor-alpha/physiology; Angiopoietin-1/physiology; Angiopoietin-2/deficiency; Angiopoietin-2/genetics; Animals; Cytokines/physiology; Endothelium, Vascular/pathology; Endothelium, Vascular/physiopathology; Humans; Inflammation/pathology; Inflammation/physiopathology; Inflammation Mediators/physiology; Mice; Mice, Knockout; Models, Biological; Neovascularization, Pathologic; Signal Transduction

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Database: MEDLINE Main subject: Tumor Necrosis Factor-alpha / Angiopoietin-2 / Inflammation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2006 Type: Article Affiliation country: Germany

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