The Ret(C620R) mutation affects renal and enteric development in a mouse model of Hirschsprung's disease.

Carniti, Cristiana; Belluco, Sara; Riccardi, Elena; Cranston, Aaron N; Mondellini, Piera; Ponder, Bruce A J; Scanziani, Eugenio; Pierotti, Marco A; Bongarzone, Italia

Carniti, Cristiana; Belluco, Sara; Riccardi, Elena; Cranston, Aaron N; Mondellini, Piera; Ponder, Bruce A J; Scanziani, Eugenio; Pierotti, Marco A; Bongarzone, Italia.

Affiliation

Carniti C; Department of Experimental Oncology and Laboratories, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133 Milan, Italy. cristiana.carniti@istitutotumori.mi.it

Am J Pathol ; 168(4): 1262-75, 2006 Apr.

Article in En | MEDLINE | ID: mdl-16565500

Subject(s)

Gastrointestinal Tract/embryology; Hirschsprung Disease/pathology; Kidney/embryology; Proto-Oncogene Proteins c-ret/genetics; Amino Acid Substitution; Animals; Cells, Cultured; Disease Models, Animal; Enteric Nervous System/abnormalities; Enteric Nervous System/embryology; Enteric Nervous System/metabolism; Female; Ganglia, Spinal/metabolism; Ganglia, Spinal/pathology; Gastrointestinal Tract/innervation; Gastrointestinal Tract/metabolism; Hirschsprung Disease/embryology; Hirschsprung Disease/genetics; Kidney/pathology; Male; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-ret/metabolism; Thyroid Gland/abnormalities; Thyroid Gland/embryology; Thyroid Gland/metabolism

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Full text: 1 Database: MEDLINE Main subject: Gastrointestinal Tract / Proto-Oncogene Proteins c-ret / Hirschsprung Disease / Kidney Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Pathol Year: 2006 Type: Article Affiliation country: Italy

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