Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity.

Roberts, Diane M; Nanda, Anjali; Havenga, Menzo J E; Abbink, Peter; Lynch, Diana M; Ewald, Bonnie A; Liu, Jinyan; Thorner, Anna R; Swanson, Patricia E; Gorgone, Darci A; Lifton, Michelle A; Lemckert, Angelique A C; Holterman, Lennart; Chen, Bing; Dilraj, Athmanundh; Carville, Angela; Mansfield, Keith G; Goudsmit, Jaap; Barouch, Dan H

Roberts, Diane M; Nanda, Anjali; Havenga, Menzo J E; Abbink, Peter; Lynch, Diana M; Ewald, Bonnie A; Liu, Jinyan; Thorner, Anna R; Swanson, Patricia E; Gorgone, Darci A; Lifton, Michelle A; Lemckert, Angelique A C; Holterman, Lennart; Chen, Bing; Dilraj, Athmanundh; Carville, Angela; Mansfield, Keith G; Goudsmit, Jaap; Barouch, Dan H.

Affiliation

Roberts DM; Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature ; 441(7090): 239-43, 2006 May 11.

Article in En | MEDLINE | ID: mdl-16625206

Subject(s)

Adenoviridae/genetics; Adenoviridae/immunology; Capsid Proteins/genetics; Capsid Proteins/immunology; Genetic Engineering; Genetic Vectors/genetics; Genetic Vectors/immunology; Adenoviridae/classification; Adenoviridae/physiology; Animals; CD8-Positive T-Lymphocytes/immunology; DNA, Recombinant/genetics; Genetic Therapy; Macaca mulatta/immunology; Mice; Mice, Inbred C57BL; Neutralization Tests; Vaccines

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Genetic Engineering / Adenoviridae / Capsid Proteins / Genetic Vectors Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Nature Year: 2006 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links