Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity.

Mutlib, Abdul E; Goosen, Theunis C; Bauman, Jonathan N; Williams, J Andrew; Kulkarni, Shaila; Kostrubsky, Seva

Mutlib, Abdul E; Goosen, Theunis C; Bauman, Jonathan N; Williams, J Andrew; Kulkarni, Shaila; Kostrubsky, Seva.

Affiliation

Mutlib AE; Department of Pharmacokinetics, Pfizer Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA. abdul.mutlib@pfizer.com

Chem Res Toxicol ; 19(5): 701-9, 2006 May.

Article in En | MEDLINE | ID: mdl-16696573

Subject(s)

Acetaminophen/pharmacokinetics; Glucuronides/metabolism; Glucuronosyltransferase/metabolism; Analgesics, Non-Narcotic/pharmacokinetics; Biotransformation; Cells, Cultured; Hepatocytes/metabolism; Humans; Microsomes, Liver/metabolism

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Glucuronosyltransferase / Glucuronides / Acetaminophen Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2006 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links