Boswellic acids stimulate arachidonic acid release and 12-lipoxygenase activity in human platelets independent of Ca2+ and differentially interact with platelet-type 12-lipoxygenase.

Poeckel, Daniel; Tausch, Lars; Kather, Nicole; Jauch, Johann; Werz, Oliver

Poeckel, Daniel; Tausch, Lars; Kather, Nicole; Jauch, Johann; Werz, Oliver.

Affiliation

Poeckel D; Department of Pharmaceutical Analytics, Institute of Pharmacy, Eberhard-Karls-University Tubingen, Auf der Morgenstelle 8, D-72076 Tubingen, Germany.

Mol Pharmacol ; 70(3): 1071-8, 2006 Sep.

Article in En | MEDLINE | ID: mdl-16788089

Subject(s)

Arachidonate 12-Lipoxygenase/metabolism; Arachidonic Acid/metabolism; Blood Platelets/drug effects; Blood Platelets/enzymology; Calcium/metabolism; Triterpenes/pharmacology; Blood Platelets/metabolism; Cell-Free System; Humans; Kinetics; Leukotrienes/biosynthesis; Phospholipases A/metabolism; Phospholipases A2; Signal Transduction/drug effects; Triterpenes/chemistry

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Database: MEDLINE Main subject: Triterpenes / Blood Platelets / Arachidonate 12-Lipoxygenase / Calcium / Arachidonic Acid Type of study: Prognostic_studies Limits: Humans Language: En Journal: Mol Pharmacol Year: 2006 Type: Article Affiliation country: Germany

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