Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.
Cancer Res
; 51(19): 5171-6, 1991 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-1680546
ABSTRACT
The p53 gene on chromosome 17p is considered to be a tumor suppressor gene, and frequent mutations of the p53 gene have been found in a wide variety of human cancers. We examined 31 ovarian cancers for allelic losses and mutations of the p53 gene by polymerase chain reaction-single strand conformation polymorphism analysis as well as restriction fragment length polymorphism analysis. Allelic loss of the p53 gene was detected in 16 of 20 cases (80%). Mutations were detected in 9 of 31 cases (29%) 2 cases in exon 4; 5 cases in exons 5-6; and 2 cases in exons 7-8. In 8 of 9 cases, p53 mutations were accompanied by losses of the normal allele. These alterations of the p53 gene were commonly detected from stage I to stage IV. These results suggest that alterations of the p53 gene play an important role in the development of human ovarian cancers.
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Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Chromosomes, Human, Pair 17
/
Genes, p53
/
Mutation
Limits:
Female
/
Humans
Language:
En
Journal:
Cancer Res
Year:
1991
Type:
Article
Affiliation country:
Japan