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The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts.
Savi, Pierre; Zachayus, Jean-Luc; Delesque-Touchard, Nathalie; Labouret, Catherine; Hervé, Caroline; Uzabiaga, Marie-Françoise; Pereillo, Jean-Marie; Culouscou, Jean-Michel; Bono, Françoise; Ferrara, Pascual; Herbert, Jean-Marc.
Affiliation
  • Savi P; Department of Thrombosis and Angiogenesis, Sanofi-Aventis Recherche, 195 Route d'Espagne, 31036 Toulouse, France. pierre.savi@sanofi-aventis.com
Proc Natl Acad Sci U S A ; 103(29): 11069-74, 2006 Jul 18.
Article in En | MEDLINE | ID: mdl-16835302
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Full text: 1 Database: MEDLINE Main subject: Ticlopidine / Receptors, Purinergic P2 / Membrane Microdomains Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Type: Article Affiliation country: France
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Full text: 1 Database: MEDLINE Main subject: Ticlopidine / Receptors, Purinergic P2 / Membrane Microdomains Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2006 Type: Article Affiliation country: France