Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.

Fotoohi, Alan Kambiz; Wrabel, Anna; Moshfegh, Ali; Peterson, Curt; Albertioni, Freidoun

Fotoohi, Alan Kambiz; Wrabel, Anna; Moshfegh, Ali; Peterson, Curt; Albertioni, Freidoun.

Affiliation

Fotoohi AK; Department of Oncology and Pathology, Cancer Center Karolinska (CCK), Karolinska Hospital and Institute, 171 76 Stockholm, Sweden.

Biochem Pharmacol ; 72(7): 816-23, 2006 Sep 28.

Article in En | MEDLINE | ID: mdl-16859645

Subject(s)

Drug Resistance, Neoplasm/drug effects; Mercaptopurine/analogs & derivatives; Mercaptopurine/pharmacology; T-Lymphocytes/drug effects; Adenosine Kinase/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Down-Regulation/drug effects; Equilibrative Nucleoside Transporter 1/antagonists & inhibitors; Equilibrative Nucleoside Transporter 1/genetics; Equilibrative Nucleoside Transporter 1/metabolism; Gene Silencing; Humans; Inhibitory Concentration 50; Polymerase Chain Reaction/methods; Purines/antagonists & inhibitors; Purines/biosynthesis; RNA, Messenger/antagonists & inhibitors; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/genetics; Ribonucleotides/antagonists & inhibitors; Ribonucleotides/biosynthesis; Sodium/physiology; T-Lymphocytes/metabolism; T-Lymphocytes/pathology; Thioguanine/pharmacology

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Database: MEDLINE Main subject: T-Lymphocytes / Drug Resistance, Neoplasm / Mercaptopurine Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2006 Type: Article Affiliation country: Sweden

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