Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia.

Ihnatko, Robert; Kubes, Miroslav; Takacova, Martina; Sedlakova, Olga; Sedlak, Jan; Pastorek, Jaromir; Kopacek, Juraj; Pastorekova, Silvia

Ihnatko, Robert; Kubes, Miroslav; Takacova, Martina; Sedlakova, Olga; Sedlak, Jan; Pastorek, Jaromir; Kopacek, Juraj; Pastorekova, Silvia.

Affiliation

Ihnatko R; Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, 845 05 Bratislava, Slovak Republic.

Int J Oncol ; 29(4): 1025-33, 2006 Oct.

Article in En | MEDLINE | ID: mdl-16964400

Subject(s)

Acidosis/enzymology; Antigens, Neoplasm/genetics; Carbonic Anhydrases/genetics; Central Nervous System Neoplasms/enzymology; Glioblastoma/enzymology; Transcription, Genetic; Acidosis/genetics; Antigens, Neoplasm/analysis; Carbonic Anhydrase IX; Carbonic Anhydrases/analysis; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Central Nervous System Neoplasms/genetics; Central Nervous System Neoplasms/pathology; Glioblastoma/genetics; Glioblastoma/pathology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Promoter Regions, Genetic

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Database: MEDLINE Main subject: Transcription, Genetic / Acidosis / Central Nervous System Neoplasms / Carbonic Anhydrases / Glioblastoma / Antigens, Neoplasm Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2006 Type: Article

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