Spironolactone induces apoptosis and inhibits NF-kappaB independent of the mineralocorticoid receptor.

Sønder, Søren Ulrik Salling; Woetmann, Anders; Odum, Niels; Bendtzen, Klaus

Sønder, Søren Ulrik Salling; Woetmann, Anders; Odum, Niels; Bendtzen, Klaus.

Affiliation

Sønder SU; Institute for Inflammation Research, IIR7521, Rigshospitalet National University Hospital, Blegdamsvej, 9, DK-2100, Copenhagen E, Denmark.

Apoptosis ; 11(12): 2159-65, 2006 Dec.

Article in En | MEDLINE | ID: mdl-17051331

Subject(s)

Apoptosis/drug effects; NF-kappa B/antagonists & inhibitors; Receptors, Mineralocorticoid/metabolism; Spironolactone/pharmacology; Caspase 3/metabolism; Cytokines/biosynthesis; Humans; I-kappa B Proteins/metabolism; Leukocytes, Mononuclear/drug effects; Mineralocorticoid Receptor Antagonists/pharmacology; NF-KappaB Inhibitor alpha; Phosphorylation/drug effects; Sulfasalazine/pharmacology

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Database: MEDLINE Main subject: Spironolactone / NF-kappa B / Apoptosis / Receptors, Mineralocorticoid Limits: Humans Language: En Journal: Apoptosis Year: 2006 Type: Article Affiliation country: Denmark

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