3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

Ellsworth, Edmund L; Tran, Tuan P; Showalter, H D Hollis; Sanchez, Joseph P; Watson, Brian M; Stier, Michael A; Domagala, John M; Gracheck, Stephen J; Joannides, E Themis; Shapiro, Martin A; Dunham, Steve A; Hanna, Debra L; Huband, Michael D; Gage, Jeffrey W; Bronstein, Joel C; Liu, Jia Yeu; Nguyen, Dai Q; Singh, Rajeshwar

Ellsworth, Edmund L; Tran, Tuan P; Showalter, H D Hollis; Sanchez, Joseph P; Watson, Brian M; Stier, Michael A; Domagala, John M; Gracheck, Stephen J; Joannides, E Themis; Shapiro, Martin A; Dunham, Steve A; Hanna, Debra L; Huband, Michael D; Gage, Jeffrey W; Bronstein, Joel C; Liu, Jia Yeu; Nguyen, Dai Q; Singh, Rajeshwar.

Affiliation

Ellsworth EL; Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. edmund.ellsworth@pfizer.com

J Med Chem ; 49(22): 6435-8, 2006 Nov 02.

Article in En | MEDLINE | ID: mdl-17064062

Subject(s)

Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Bacteria/drug effects; Quinazolinones/chemical synthesis; DNA Topoisomerase IV/antagonists & inhibitors; Drug Resistance, Multiple, Bacterial/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Methicillin Resistance; Microbial Sensitivity Tests; Structure-Activity Relationship; Topoisomerase II Inhibitors

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Database: MEDLINE Main subject: Bacteria / Quinazolinones / Anti-Bacterial Agents Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Type: Article Affiliation country: United States

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