Design and synthesis of a novel class of dual PPARgamma/delta agonists.

Gonzalez, Isabel C; Lamar, Jason; Iradier, Fatima; Xu, Yanping; Winneroski, Leonard L; York, Jeremy; Yumibe, Nathan; Zink, Richard; Montrose-Rafizadeh, Chahrzad; Etgen, Gary J; Broderick, Carol L; Oldham, Brian A; Mantlo, Nathan

Gonzalez, Isabel C; Lamar, Jason; Iradier, Fatima; Xu, Yanping; Winneroski, Leonard L; York, Jeremy; Yumibe, Nathan; Zink, Richard; Montrose-Rafizadeh, Chahrzad; Etgen, Gary J; Broderick, Carol L; Oldham, Brian A; Mantlo, Nathan.

Affiliation

Gonzalez IC; Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate center, Indianapolis, IN 46285, USA. gonzalez_isabel_c@lilly.com

Bioorg Med Chem Lett ; 17(4): 1052-5, 2007 Feb 15.

Article in En | MEDLINE | ID: mdl-17129725

Subject(s)

Hypoglycemic Agents/chemical synthesis; Hypoglycemic Agents/pharmacology; PPAR delta/agonists; PPAR gamma/agonists; Animals; Blood Glucose/metabolism; Dose-Response Relationship, Drug; Drug Design; Female; Half-Life; Humans; Hypoglycemic Agents/pharmacokinetics; Indicators and Reagents; Insulin/blood; Male; Rats; Rats, Sprague-Dawley; Rats, Zucker; Rosiglitazone; Structure-Activity Relationship; Thiazolidinediones/pharmacology; Weight Gain/drug effects

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Database: MEDLINE Main subject: PPAR delta / PPAR gamma / Hypoglycemic Agents Limits: Animals / Female / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Type: Article Affiliation country: United States

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