Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

Sørensen, Heidi; Winzell, Maria Sörhede; Brand, Christian L; Fosgerau, Keld; Gelling, Richard W; Nishimura, Erica; Ahren, Bo

Sørensen, Heidi; Winzell, Maria Sörhede; Brand, Christian L; Fosgerau, Keld; Gelling, Richard W; Nishimura, Erica; Ahren, Bo.

Affiliation

Sørensen H; Diabetes Research Unit, Novo Nordisk Park, 2760 Måløv, Denmark. hesn@novonordisk.com

Diabetes ; 55(12): 3463-9, 2006 Dec.

Article in En | MEDLINE | ID: mdl-17130493

Subject(s)

Insulin-Secreting Cells/metabolism; Insulin/pharmacology; Receptors, Glucagon/deficiency; Receptors, Glucagon/genetics; Animals; Arginine/pharmacology; Blood Glucose/metabolism; Carbachol/pharmacology; Glucagon/physiology; Glucose/metabolism; Glucose Clamp Technique; Glucose Tolerance Test; Hyperinsulinism; Insulin/metabolism; Insulin Secretion; Kinetics; Mice; Mice, Knockout

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Database: MEDLINE Main subject: Receptors, Glucagon / Insulin-Secreting Cells / Insulin Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Diabetes Year: 2006 Type: Article Affiliation country: Denmark

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