Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation.

Rimmelé, Pauline; Kosmider, Olivier; Mayeux, Patrick; Moreau-Gachelin, Françoise; Guillouf, Christel

Rimmelé, Pauline; Kosmider, Olivier; Mayeux, Patrick; Moreau-Gachelin, Françoise; Guillouf, Christel.

Affiliation

Rimmelé P; Institut Curie, Institut National de la Santé et de la Recherche Médicale (INSERM) Unite 528, Paris, France.

Blood ; 109(7): 3007-14, 2007 Apr 01.

Article in En | MEDLINE | ID: mdl-17132716

Subject(s)

Erythropoietin/physiology; Leukemia, Erythroblastic, Acute/etiology; Proto-Oncogene Proteins/physiology; Trans-Activators/physiology; Animals; Apoptosis/physiology; Base Sequence; Cell Cycle/physiology; Cell Differentiation; Erythroblasts/pathology; Erythroblasts/physiology; Erythropoiesis/physiology; Humans; Leukemia, Erythroblastic, Acute/genetics; Leukemia, Erythroblastic, Acute/pathology; Leukemia, Erythroblastic, Acute/physiopathology; Mice; Mice, Transgenic; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; RNA, Small Interfering/genetics; Receptors, Erythropoietin/physiology; Signal Transduction/physiology; Trans-Activators/antagonists & inhibitors; Trans-Activators/genetics

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Database: MEDLINE Main subject: Leukemia, Erythroblastic, Acute / Trans-Activators / Proto-Oncogene Proteins / Erythropoietin Limits: Animals / Humans Language: En Journal: Blood Year: 2007 Type: Article Affiliation country: France

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