Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Noguera-Troise, Irene; Daly, Christopher; Papadopoulos, Nicholas J; Coetzee, Sandra; Boland, Pat; Gale, Nicholas W; Lin, Hsin Chieh; Yancopoulos, George D; Thurston, Gavin

Noguera-Troise, Irene; Daly, Christopher; Papadopoulos, Nicholas J; Coetzee, Sandra; Boland, Pat; Gale, Nicholas W; Lin, Hsin Chieh; Yancopoulos, George D; Thurston, Gavin.

Affiliation

Noguera-Troise I; Regeneron Research Laboratories, 777 Old Saw Mill River Road, Tarrytown, New York 10591, USA.

Nature ; 444(7122): 1032-7, 2006 Dec 21.

Article in En | MEDLINE | ID: mdl-17183313

Subject(s)

Membrane Proteins/metabolism; Neoplasms/blood supply; Neoplasms/pathology; Neovascularization, Pathologic; Adenoviridae/genetics; Animals; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation; Genes, Reporter/genetics; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Mice; Neoplasms/drug therapy; Neovascularization, Pathologic/drug therapy; Rats; Receptors, Notch/metabolism; Signal Transduction; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Vascular Endothelial Growth Factor A/metabolism

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Database: MEDLINE Main subject: Membrane Proteins / Neoplasms / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nature Year: 2006 Type: Article Affiliation country: United States

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